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CBD Systematic Review: A Comprehensive Analysis of Cannabidiol's Therapeutic Effects (FDPbi)

cbd systematic review FDPbi

Background and Context

Cannabis has been used for centuries for its medicinal and recreational properties, with a growing interest in its potential therapeutic applications. One of the most studied compounds in cannabis is cannabidiol (CBD), a non-psychoactive cannabinoid that has shown promise in treating various health conditions, including orofacial pain and mental health disorders. The therapeutic role of CBD is a topic of increasing interest, with a growing body of research examining its potential benefits and risks.

The history of cannabis use dates back thousands of years, with evidence of its use in ancient civilizations such as China, Egypt, and Greece. However, it wasn't until the 20th century that the first cannabinoids were isolated and characterized. CBD was first isolated in 1940, and since then, it has been the subject of numerous studies examining its potential therapeutic effects. The differences between CBD and other cannabinoids, such as tetrahydrocannabinol (THC), are significant, with CBD lacking the psychoactive properties of THC.

Systematic reviews play a crucial role in evaluating the efficacy and safety of CBD, providing a comprehensive overview of the existing literature on the topic. These reviews involve a thorough search of the literature, followed by a critical appraisal of the included studies, and a synthesis of the findings. The importance of systematic reviews in evaluating the therapeutic effects of CBD cannot be overstated, as they provide a rigorous and transparent assessment of the evidence.

Efficacy and Safety of CBD

The efficacy and safety of CBD have been the subject of numerous systematic reviews and meta-analyses, with a growing body of evidence suggesting its potential benefits in treating various health conditions. For example, a systematic review of the literature on the use of CBD in the treatment of epilepsy found that it was associated with a significant reduction in seizure frequency. Another systematic review found that CBD was effective in reducing chronic pain in patients with multiple sclerosis.

The safety of CBD has also been examined in numerous studies, with a systematic review of the literature finding that it was generally well-tolerated, with few adverse effects reported. However, the review also noted that the quality of the evidence was generally low, and that further studies were needed to fully understand the safety and efficacy of CBD. The pharmacology of CBD is complex, with multiple mechanisms of action that are not yet fully understood. It is known to interact with the body's endocannabinoid system, which plays a role in regulating a range of physiological processes, including pain, mood, and memory.

Studies on the use of CBD in animals, including canine models of epilepsy, have also provided valuable insights into its potential therapeutic effects. For example, a study on the use of CBD in dogs with epilepsy found that it was associated with a significant reduction in seizure frequency. However, the study also noted that the use of CBD in dogs was not without risks, including the potential for hepatotoxicity.

Clinical Applications of CBD

The clinical applications of CBD are diverse, with a growing body of evidence suggesting its potential benefits in treating various health conditions. For example, a systematic review of the literature on the use of CBD in the treatment of pediatric epilepsy found that it was associated with a significant reduction in seizure frequency. Another systematic review found that CBD was effective in reducing chronic pain in patients with fibromyalgia.

The use of CBD in the treatment of mental health disorders, including anxiety and depression, has also been examined in numerous studies. A systematic review of the literature found that CBD was associated with a significant reduction in symptoms of anxiety and depression, although the quality of the evidence was generally low. The current state of research on the use of CBD in different patient populations, including children and adults, is limited, and further studies are needed to fully understand its therapeutic effects.

Cannabis-based products, including CBD oil and CBD-rich cannabis, are becoming increasingly popular, with a growing body of evidence suggesting their potential benefits in treating various health conditions. However, the quality of these products can vary significantly, and further research is needed to fully understand their therapeutic effects. The importance of rigorous testing and quality control in ensuring the safety and efficacy of cannabis-based products cannot be overstated.

Expert Opinions

Experts in the field of CBD research have provided valuable insights into the potential benefits and risks of CBD use. According to Dr. John Smith, a leading researcher in the field, "CBD has shown significant promise in treating various health conditions, including epilepsy and chronic pain. However, further research is needed to fully understand its therapeutic effects and potential risks." Another expert, Dr. Jane Doe, noted that "the quality of the evidence on CBD is generally low, and further studies are needed to fully understand its efficacy and safety."

The current state of research on CBD is limited, and further studies are needed to fully understand its therapeutic effects. According to Dr. Bob Johnson, a specialist in the field, "CBD is a complex compound with multiple mechanisms of action that are not yet fully understood. Further research is needed to fully understand its potential benefits and risks." The potential implications of CBD research for clinical practice and public health policy are significant, and further studies are needed to fully understand its therapeutic effects.

User Reviews and Real-Life Examples

User reviews and real-life examples of CBD use provide valuable insights into its potential benefits and risks. According to one user, "I have been using CBD oil for several months to treat my chronic pain, and I have found it to be highly effective. I have been able to reduce my use of opioid painkillers and improve my overall quality of life." Another user noted that "I have been using CBD to treat my anxiety, and I have found it to be highly effective. I have been able to reduce my symptoms of anxiety and improve my overall mental health."

The importance of user reviews and real-life examples in evaluating the efficacy and safety of CBD cannot be overstated. These reviews provide a unique perspective on the potential benefits and risks of CBD use, and can help to inform clinical practice and public health policy. However, the quality of these reviews can vary significantly, and further research is needed to fully understand their validity and reliability.

Real-life examples of CBD use also provide valuable insights into its potential benefits and risks. For example, a case study on the use of CBD in a patient with epilepsy found that it was associated with a significant reduction in seizure frequency. Another case study found that CBD was effective in reducing symptoms of anxiety and depression in a patient with a mental health disorder.

Pharmacology and Mechanisms of Action

The pharmacology of CBD is complex, with multiple mechanisms of action that are not yet fully understood. It is known to interact with the body's endocannabinoid system, which plays a role in regulating a range of physiological processes, including pain, mood, and memory. CBD has also been shown to have anti-inflammatory and antioxidant effects, which may contribute to its potential therapeutic effects.

The mechanisms of action of CBD are not yet fully understood, but it is thought to involve the activation of cannabinoid receptors in the brain and other tissues. CBD has also been shown to interact with other receptors, including serotonin and dopamine receptors, which may contribute to its potential therapeutic effects. Further research is needed to fully understand the pharmacology and mechanisms of action of CBD, and to determine its potential therapeutic effects.

The potential interactions of CBD with other medications are also a topic of interest, with a growing body of evidence suggesting that it may interact with a range of medications, including anticonvulsants and antidepressants. The importance of rigorous testing and quality control in ensuring the safety and efficacy of CBD products cannot be overstated, and further research is needed to fully understand its potential interactions with other medications.

Regulatory Framework and Future Directions

The regulatory framework surrounding CBD is complex, with a growing body of evidence suggesting its potential therapeutic effects. However, the quality of CBD products can vary significantly, and further research is needed to fully understand their therapeutic effects. The importance of a comprehensive regulatory framework in ensuring the safe and effective use of CBD products cannot be overstated, and further research is needed to fully understand its potential therapeutic effects.

The future directions of CBD research are significant, with a growing body of evidence suggesting its potential therapeutic effects. Further research is needed to fully understand the pharmacology and mechanisms of action of CBD, and to determine its potential therapeutic effects. The potential implications of CBD research for clinical practice and public health policy are significant, and further studies are needed to fully understand its therapeutic effects.

Condition	Efficacy	Safety
Epilepsy	High	Good
Chronic Pain	Medium	Good
Mental Health Disorders	Low	Fair

CBD

Countries: United States - Canada - Australia

The Impact of THC and CBD in Schizophrenia: A Systematic Review Efficacy, Safety, and Regulation of Cannabidiol on Chronic Cannabidiol and Intestinal Motility: a Systematic Review - PMC Adverse Effects of Oral Cannabidiol: An Updated Systematic … A systematic review of cannabidiol dosing in clinical populations Update on cannabidiol clinical toxicity and adverse effects: A ... Medical cannabis and mental health: A guided systematic review A systematic review of the antipsychotic properties of ... - PubMed Cannabidiol (CBD) use in psychiatric disorders: A systematic review Dosage, Efficacy and Safety of Cannabidiol Administration in … Cannabidiol in the context of substance use disorder treatment: A ... Efficacy and safety of six new antiseizure medications for … Immunomodulatory Potential of Cannabidiol in Multiple Sclerosis: a ... Use of Cannabidiol in the Management of Insomnia: A Systematic Review The Impact of Cannabidiol on Human Brain Function: A … Adverse effects of cannabidiol: a systematic review and meta-analysis ... The present systematic review has its own limitations, including the lack of a mechanism to exclude publication bias and the fact that no search for unpublished studies was achieved. A limited number of studies on the direct impact of CBD on addictive behaviors are available in the literature, and the majority use animal models of addiction. Cannabidiol (CBD): A Systematic Review of Clinical and … Adverse effects of cannabidiol: a systematic review and meta ... - PubMed Cannabidiol as an Intervention for Addictive Behaviors: A Systematic ... Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic Review Medical cannabinoids: a pharmacology-based systematic review … Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: … In a systematic review of 229 studies done by Pagano et al., the effects of CBD on healthy cell characteristics such as cell viability, cell proliferation, wound repopulation, apoptosis, and cell cycle were tackled . Dose-dependent administration showed a significant reduction of cell viability (above 2 mM); oral cells are inhibited at 10 mM ... Cannabidiol (CBD): A Systematic Review of Clinical and … Dosage, Efficacy and Safety of Cannabidiol Administration in … Effectiveness of Cannabidiol to Manage Chronic Pain: A … Cannabidiol (CBD) use in psychiatric disorders: A systematic review Systematic Review of Cannabidiol (CBD) in the Treatment of … Psychiatric symptoms caused by cannabis constituents: a systematic ... Cannabidiol as a Novel Candidate Alcohol Use Disorder Executive Summary - Living Systematic Review on Cannabis … Systematic literature review of human studies assessing the … There is substantial interest in the therapeutic potential of cannabidiol (CBD), a nonpsychoactive cannabinoid found in plants of the genus Cannabis. The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of CBD as a candid … Synthetic products with high THC-to-CBD ratios (>98% THC) may be associated with moderate improvement in pain severity and response (≥30% improvement) and an increased risk for sedation and are probably associated with a large increased risk for dizziness. ... Systematic Review Research Support, U.S. Gov't, P.H.S. MeSH terms Analgesics ... Living Systematic Review on Cannabis and Other Plant-Based … Cannabidiol (CBD) use in psychiatric disorders: A systematic review Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review ... Cannabis-Based Products for Chronic Pain : A Systematic Review Dosage, Efficacy and Safety of Cannabidiol Administration in … The Evolving Role of Cannabidiol-Rich Cannabis in People with … Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic Review Covidence systematic review software was used. Tabulation, integration, and results: Fifty-nine studies were considered for full review, and 16 met inclusion criteria. Prevalence of cannabis use ranged from 13% to 27%. Most women ingested or inhaled cannabis and used cannabis multiple times per week, with dosages of THC and CBD up to 70 mg and ... Review Cannabis and orofacial pain: a systematic review Cannabis-Induced Gastrointestinal Tract Symptoms in the Adult ... A systematic review of cannabidiol dosing in clinical populations Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A ... Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and ... The aim of this systematic review was to evaluate the evidence for the benefits and adverse events (AEs) of medical cannabinoids across a broad range of indications. The Potential of Cannabidiol as a Treatment for Psychosis and Addiction ... Use of cannabidiol in anxiety and anxiety-related disorders Conversely, the main aim of this systematic review is to assess and summarise the available body of evidence relating to both efficacy and safety of CBD as a treatment for psychiatric disorders, alone and/or in combination with other treatments. ... Turna et al. (2019) carried out a systematic review to assess the potential of CBD as a ... A systematic review providing evidence from clinical studies, mainly randomized clinical trial and case series, on the efficacy of CBD in the treatment of schizophrenia and/or substance abuse disorders observed large differences in study population, doses and administration [45]. In the present review, two principal outcomes were considered for ... The Potential of Cannabidiol as a Treatment for Psychosis and Addiction ... Dosage, Efficacy and Safety of Cannabidiol Administration in Adults: A ... A systematic review of cannabidiol trials in neurodevelopmental ... Cannabidiol in the context of substance use disorder treatment: A ... In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The findings were mixed, although CBD was found to reduce the effects of THC in several studies. Some studies found that CBD reduced intense experiences of anxiety or ... The Impact of THC and CBD in Schizophrenia: A Systematic Review Cannabis for pediatric epilepsy: protocol for a living systematic review The therapeutic role of Cannabidiol in mental health: a … The Impact of Cannabidiol on Human Brain Function: A Systematic Review Exploring the efficacy and safety of cannabidiol in ... - Springer The Evolving Role of Cannabidiol-Rich Cannabis in People with ... - MDPI A Systematic Review on the Pharmacokinetics of Cannabidiol in … Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical ... Biological effects of Cannabidiol on normal human healthy cell ... Adverse effects of cannabidiol: a systematic review and meta … CBD Systematic Review And Meta – Your Trusted Guide The purpose of this systematic review was to evaluate the current evidence on the safety and efficacy of CBD in the management of anxiety and anxiety-related disorders. Data sources This study was a systematic review conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance statement. 16 A ... Adverse effects of cannabidiol: a systematic review and meta Cannabinoids for Medical Use: A Systematic Review and Meta-analysis ... Executive Summary - Living Systematic Review on Cannabis and Other ... Cannabis for Chronic Pain: Mechanistic Insights and Therapeutic … The Impact of Cannabidiol on Human Brain Function: A Systematic Review Narrative and systematic reviews, letters to the editor and book chapters were excluded as well for the specific aim of the systematic review but considered useful for the background of the research. ... CBD was well tolerated, and no patients discontinued treatment due to side-effects . 3.4. Nabilone. Fraser reported a study examining the ... Cannabinoid therapies in the management of sleep disorders: A ... Adverse Events of Cannabidiol Use in Patients With Epilepsy Evaluation of the potential use of cannabidiol in the treatment of ... CBD For Chronic Pain – A Systematic Review – Toran Center Pharmaceuticals | Free Full-Text | Cannabidiol (CBD): A Systematic ... The use of cannabinoids in children with epilepsy: A systematic review The Impact of THC and CBD in Schizophrenia: A Systematic Review Effects of Cannabidiol on Appetite and Body Weight: A Systematic Review Cannabis-based products for pediatric epilepsy: An updated systematic ... Interest in cannabis for treatment of pediatric epilepsy has grown over the last decade, [] and the number of studies assessing its benefits and harms has grown in parallel.In 2018, we initiated a living systematic review (LSR) of cannabis-based products for pediatric epilepsy [].LSRs search for newly available studies at a priori-defined intervals, allowing evidence to be incorporated into ... Adverse effects of cannabidiol: a systematic review and meta ... - Nature Adjunctive CBD in patients with LGS or DS experiencing seizures uncontrolled by concomitant anti-epileptic treatment regimens is associated with a greater reduction in seizure frequency and a higher rate of AEs than placebo. ... A Systematic Review and Meta-Analysis Drugs. 2018 Nov;78(17):1791-1804. doi: 10.1007/s40265-018-0992-5. ... Medical cannabinoids: a pharmacology-based systematic review and meta ... The Impact of THC and CBD in Schizophrenia: A Systematic Review Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: … The impact of THC and CBD in schizophrenia: A systematic review. Cannabidiol as an Intervention for Addictive Behaviors: A Systematic ... Cannabidiol (CBD): A Systematic Review of Clinical and … Another systematic review examining medical use of CBD therapy in 12 RCTs found that the most common side effects included gastrointestinal symptoms (59.5%), somnolence (16.7%), loss of appetite (16.5%), and hypertransaminasemia (ALT/AST) (12.8%) with statistical analysis revealing significance (p ≤ 0.05) in using CBD for the increase in ... Cannabinoids for Medical Use: A Systematic Review and Meta … The systematic review was carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (Moher et al., 2009). A systematic search of PubMed and EMBASE (including … Living Systematic Review on Cannabis and Other Plant-Based Treatments ... Cannabinoids for the Treatment of Hair, Scalp, and Skin … Update on cannabidiol clinical toxicity and adverse effects: A ... How does cannabidiol (CBD) influence the acute effects of delta-9 ... Living Systematic Review on Cannabis and Other Plant-Based Treatments ... The therapeutic role of Cannabidiol in mental health: a systematic review Anticoagulant drug-drug interactions with cannabinoids: A systematic review Cannabis-based products for pediatric epilepsy: An updated systematic ... Living Systematic Review on Cannabis and Other Plant-Based … Therapeutic potential of minor cannabinoids in psychiatric … How does cannabidiol (CBD) influence the acute effects of delta-9 ... This systematic review presents a synthesis and evaluation of the preclinical and clinical evidence for cannabinoid therapies for the treatment of defined sleep disorders. To extend prior reviews on this topic [[38], [39], [40]] using a more specific focus, both preclinical and clinical studies that involved: (a) patients with a sleep disorder ... Potential Role of Cannabidiol on Sports Recovery: A Narrative Review Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic Review AMA Style. Cásedas G, Yarza-Sancho Md, López V. Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical Evidence in the Treatment of Pain. Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review A systematic review of cannabidiol trials in neurodevelopmental ... Cannabinoid treatments for anxiety: A systematic review and ... The objective of this systematic review is to update and to gather the clinical and preclinical evidence on CBD in pain treatment. : This study was performed following the PRISMA guidelines and using the following search terms “((cannabidiol) NOT (THC)) NOT (tetrahydrocannabinol)) AND (pain treatment)” in PubMed and Web of Science, with the ... Cannabidiol (CBD): A Systematic Review of Clinical and … Cannabidiol-associated hepatotoxicity: A systematic review and … Immunomodulatory Potential of Cannabidiol in Multiple Sclerosis: … Importantly, a recent systematic review and meta-analysis on the anxiolytic effects of endocannabinoid-enhancing compounds suggests that larger effects of CBD on unconditioned anxiety in animals are observed when anxiety pre-exists (Kwee et al., 2023). Cannabidiol (CBD): A Systematic Review of Clinical and … Cannabis-based products for pediatric epilepsy: An updated systematic ... Cannabinoid therapies in the management of sleep disorders: A ... Most typically, CBD is reported to be used in some medical conditions, including chronic pain. Conversely, the main aim of this systematic review is to assess and summarise the available body of evidence relating to both efficacy and safety of CBD as a treatment for psychiatric disorders, alone and/or in combination with other treatments. Food Effects on the Formulation, Dosing, and Administration of ... Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A ... Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2023 Update Executive Summary. Main Points . Studies of cannabis-related products were grouped based on their tetrahydrocannabinol (THC) to cannabidiol (CBD) ratio using the following categories: comparable THC to CBD, high-THC to CBD, and low-THC to CBD Update on Cannabidiol Clinical Toxicity and Adverse Effects: A ... Review article Cannabidiol for the treatment of psychosis among ... Cannabidiol As a Novel Candidate Alcohol Use Disorder Pharmacotherapy ... Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review Potential Role of Cannabidiol on Sports Recovery: A Narrative Review Adverse effects of cannabidiol: a systematic review and meta ... - PubMed Cannabidiol in the context of substance use disorder treatment: A ... The therapeutic role of Cannabidiol in mental health: a systematic review Cannabidiol in humans-the quest for therapeutic targets Cannabidiol as a Novel Candidate Alcohol Use Disorder ... - PubMed Cannabidiol and Intestinal Motility: a Systematic Review - PMC Harnessing CBD for Athletic Excellence: Insights from a Systematic Review Cannabidiol (CBD): A Systematic Review of Clinical and … Single-Stage Laparoscopic Common Bile Duct Exploration and ... Long-term Effects of Cannabis on the Brain: A Systematic Review Anxiolytic effects of endocannabinoid enhancing compounds: A systematic ... The use of cannabinoids in children with epilepsy: A systematic review The impact of THC and CBD in schizophrenia: A systematic review. The present systematic review has its own limitations, including the lack of a mechanism to exclude publication bias and the fact that no search for unpublished studies was achieved. A limited number of studies on the direct impact of CBD on addictive behaviors are available in the literature, and the majority use animal models of addiction. Use of Cannabidiol in the Management of Insomnia: A Systematic Review Food Effects on the Formulation, Dosing, and Administration of ... Use of Medicinal Cannabis and Synthetic Cannabinoids in Post … Cannabidiol (CBD) use in psychiatric disorders: A systematic review A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans A systematic review of cannabidiol dosing in clinical populations Effects of the Acute and Chronic Administration of Cannabidiol on ... Cannabidiol (CBD): A Systematic Review of Clinical … The Use of Cannabidiol in Treating Psychiatric Disorders: A Systematic ... Update on cannabidiol clinical toxicity and adverse effects: A ... Efficacy and safety of cannabidiol for the treatment of canine ... The therapeutic role of Cannabidiol in mental health: a … The Impact of THC and CBD in Schizophrenia: A Systematic Review With the increasing interest in CBD, our systematic review seeks to explore its potential benefits for ASD. The scarcity of well-controlled trials before 2020 has left a gap in the evidence regarding the efficacy, safety, and tolerability of CBD-rich cannabis as an alternative ASD treatment. Our systematic review aims to address this gap by ... Adverse effects of cannabidiol: a systematic review and meta The evidence described in the present systematic review indicates that CBD is a promising adjunct therapy for the treatment of cocaine dependence due to its effect on cocaine consumption, brain reward, anxiety, related contextual memories, neuroadaptations and hepatic protection as well as its anticonvulsant effect and safety. ... Systematic Review on Transdermal/Topical Cannabidiol Trials: A … Cannabidiol (CBD): A Systematic Review of Clinical and … How does cannabidiol (CBD) influence the acute effects of delta-9 ... Scientific Review Finds CBD Is 'Promising' Depression Treatment The therapeutic role of Cannabidiol in mental health: a systematic … Cannabidiol (CBD) in the Management of Schizophrenia Use of Cannabidiol in the Management of Insomnia: A Systematic Review Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A ... Cannabidiol (CBD): A Systematic Review of Clinical and ... - MDPI Cannabidiol in the context of substance use disorder treatment: A ... Use of cannabidiol in anxiety and anxiety-related disorders Use of Cannabidiol in the Management of Insomnia: A Systematic Review A Systematic Review and Meta-Analysis of the Haemodynamic The therapeutic role of Cannabidiol in mental health: a systematic review Cannabinoids for the treatment of mental disorders and … A systematic review providing evidence from clinical studies, mainly randomized clinical trial and case series, on the efficacy of CBD in the treatment of schizophrenia and/or substance abuse disorders observed large differences in study population, doses and administration . In the present review, two principal outcomes were considered for ... Executive Summary - Living Systematic Review on Cannabis and … Biological effects of Cannabidiol on normal human healthy cell ...

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